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The Logan System 914-12 is designed to save valuable time by delivering precise transdermal samples into HPLC vials or sample tubes automatically. The DHC-6AT Dry Heat Transdermal Drive Console is remarkably simple to use, 6 DHBFC (Dry-Heat Bubble Free Cells) are surrounded by a thermostatically controlled heater block, where temperature is maintained at 32° or 37°C. DHBF Cells are constructed with molded Teflon donors and precision cut glass bodies. Skin is mounted between the cell cap (donor) and the cell body (receptor). The dermis is bathed from below with an isotonic saline solution injected through the bottom port, which flows thru the upper port to provide contact with no bubbles under the skin membrane.
Homogenous distribution of temperature in the saline bathing solution is accomplished by the agitating motion of a Teflon-covered magnetic stirring bar, driven by an external magnet mounted on a timing- motor. The cell cap is open to the air, exposing the membrane’s upper surface to ambient conditions. The open cap also allows for a finite dose application of the compound being studied.
The SYP Series Syringe Pump Module withdraws & measures sample volumes from the transdermal diffusion cells at each time interval. Individual samples are dispensed simultaneously into HPLC vials that are stored in the SCR Series Sample Collectors. To avoid sample dilution, the replacement media takes place right after each sampling. The lift plate tilts all Dry Heat Franz Cells to allow all the air bubbles to purge out of the cells while doing media replacement. This will insure that there is no air bubbles under the skin/patch; the tilted plate goes back to the horizontal position once the media replacement is complete and continues the test.
